Generic Zyloprim is used in the treatment of many symptoms of gout, including acute attacks, tophi (collection of uric acid crystals in the tissues, especially around joints), joint destruction, and uric acid stones. Allopurinol works by reducing uric acid production in the body, thus preventing crystals from forming.
What is this medicine?
ALLOPURINOL is an enzyme blocker that lowers high levels of uric acid in your body by decreasing the amount produced. It is used to treat gout and certain types of kidney stones. This drug is also used to prevent high uric acid levels in patients who receive cancer chemotherapy. Cancer cells that are destroyed with therapy release large amounts of uric acid into the bloodstream.
What should I tell my health care provider before I take this medicine?
They need to know if you have any of these conditions:
- liver disease
- kidney disease
- unusual diets (e.g., starvation diets)
- an unusual or allergic reaction to allopurinol, other medicines, foods, dyes, or preservatives
- pregnant or trying to get pregnant
How should I take this medicine?
Take this medication by mouth usually once daily after a meal to reduce stomach upset, or as directed by your doctor. It is best to drink a full glass of water with each dose and at least another 8 glasses (8 oz. each) a day while taking this drug in order to prevent kidney stones from forming. If you are on restricted fluid intake, consult your doctor for further instructions. Your doctor may also instruct you on how to decrease acidity in your urine (e.g., avoid large amounts of ascorbic acid or Vitamin C). Dosage is based on your medical condition and response to therapy. Use this medication regularly to get the most benefit from it. Remember to take it at the same time each day. For the treatment of gout, it may take up to several weeks for this medicine to have an effect.
What if I miss a dose?
If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.
What may interact with this medicine?
Do not take it with the following:
It may also interact with:
- certain antibiotics (amoxicillin, ampicillin)
- certain asthma drugs (aminophylline, theophylline)
- "blood thinners" (e.g., warfarin)
- "water pills" (e.g., thiazide diuretics such as hydrochlorothiazide)
Tell your prescriber or health care professional about all other medicines you are taking, including non-prescription medicines, nutritional supplements, and herbal products. Also tell your prescriber or health care professional if you are a frequent user of drinks with caffeine or alcohol, if you smoke, or if you use illegal drugs. These may affect the way your medicine works. Check with your health care professional before stopping or starting any of your medicines.
What should I watch for while taking this medicine?
This drug may make you drowsy; use caution engaging in activities requiring alertness such as driving or using machinery. Alcohol may decrease the effectiveness of this drug. Limit alcoholic beverages. This medication should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor. Allopurinol passes into breast milk. Consult your doctor before breast-feeding.
You may experience an increase in the number of gouty attacks for several weeks to months after starting this medicine while the body rids itself of excess uric acid. Allopurinol is not a pain reliever. To relieve pain, continue to take your prescribed medicines for gouty attacks (e.g., colchicine, ibuprofen, indomethacin) as directed by your doctor.
What side effects may I notice from taking this medicine?
Side effects that you should report to your prescriber or health care professional as soon as possible:
- easy bleeding/bruising
- signs of infection (e.g., fever, persistent sore throat)
- change in the amount of urine
- yellowing eyes or skin
- severe stomach/abdominal pain
- persistent nausea/vomiting/lack of appetite
- dark urine
- unusual tiredness
- unusual weight loss
Side effects that usually do not require medical attention (report to your prescriber or health care professional if they continue or are bothersome):
- stomach upset
- unusual taste
- acute gouty attacks
This list may not describe all possible side effects.
Where can I keep my medicine?
Keep out of the reach of children.
Store the product at room temperature between 59-77 degrees F (15-25 degrees C) away from light and moisture. Do not store in the bathroom. Keep all medicines away from children and pets.